But Kolker wants to do more than merely provide a family history that reads like a series of gothic horror stories. Two other brothers were given the extremely dangerous though sometimes effective drug Clozapine, and not properly monitored. These issues, and the more general deficiencies of psychiatry in the closing decades of the 20th century, should have been highlighted and discussed more thoroughly than Kolker manages to do. It was not to be. . And so with each edition of the DSM, the Bible for psychiatrists, the definition of schizophrenia has changed so that it's often tailored toward the style of treatment at the time. Now we're living in a world where everything is seemingly about genetics, but we're back to a nature-nurture argument because we believe that schizophrenia and other complex diseases aren't just about genetics, but about genes that are impacted or affected by the environment. Every new interview offered a new perspective. A weekly newsletter about the powerful forces reshaping America. He takes the reader through the family’s history, beginning with the refined Mimi, a daughter of Texas aristocracy who was raised in New York, and her husband, Don, a handsome, all-American military man who taught political science and held domestic diplomatic posts. The human genome project, which took place from 1990 to 2003, and determined the base pairs that make up human DNA, and identified and mapped all of the genes of the human genome, was revolutionary, Kolker says. Kolker first learned of the Galvin family through its youngest member and second daughter, Lindsay (the first 10 children were boys). The boys’ madness surfaced with full force as each of them reached adolescence. There was a fair amount of apprehension from some of the brothers, but they deferred to their sisters. Maybe, she thought, her family’s story was not just about the secrets, not just about a disease, but about how all of that experience, with the help of Drs. I’m a reporter by training; I know about medical privacy laws. ", The Galvin family lived in Colorado Springs. In 1894, at the age of 51, he was diagnosed with a paranoid form of hallucinatory insanity and spent the next nine years in an asylum. So Kolker offered to speak on the phone for one hour with each surviving family member, beginning with their mother, Mimi, then in her 90s. Kolker mentions the Freudian attempts to attribute schizophrenia to refrigerator mothers and ineffectual or absent fathers; and though there is much in his description of Galvin family life that suggests a deeply pathological environment, he dismisses these theories as victim-blaming. A mutual friend of mine and Lindsey Galvin introduced us. What was there to learn from this family’s perfect genetic storm? Why Christopher Nolan gave in and helped a critic interpret his movies. But over the years, six of the boys in the family were diagnosed with schizophrenia. Six of the boys developed schizophrenia, as chronicled in Robert Kolker’s new book, “Hidden Valley Road.”

The two sisters wanted their family’s story told as a work of independent journalism, and they believed that every member of the family, sick and well, would participate. Six of the boys developed schizophrenia, as chronicled in Robert Kolker’s new book, “Hidden Valley Road.”.

Sign up for the Los Angeles Times Book Club. Would there have been more sensitivity about the other brothers’ states of mind?

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